Research Associate / Postdoc Computational Single Cell Omics (m/f/x)

The Biotechnology Center (BIOTEC) ( and its partner institutions, the Center for Molecular Bioengineering (B CUBE) and the Center for Regenerative Therapies Dresden (CRTD), are equipped with state-of-the-art facilities for Molecular Bioscience research ( They are part of a rich and collaborative environment that includes the Faculty of Mathematics, the Carl Gustav Carus Faculty of Medicine, the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), and the Leibniz Institute of Polymer Research Dresden (IPF). For TUD Dresden University of Technology diversity is an essential feature and a quality criterion of an excellent university. Accordingly, we welcome all applicants who would like to commit themselves, their achievements and productivity to the success of the whole institution.

At the Biotechnology Center (BIOTEC), an Institute of the Center for Molecular and Cellular Bioengineering (CMCB) , the Research Group Biomedical Genomics offers a full-time project position as

Research Associate / Postdoc Computational Single Cell Omics (m/f/x) (subject to personal qualification employees are remunerated according to salary group E 13 TV-L)

starting as soon as possible . The position is limited until December 31, 2027. An extension to approximately 4 years is anticipated. The period of employment is governed by § 2 (2) Fixed Term Research Contracts Act (Wissenschaftszeitvertragsgesetz - WissZeitVG).

Tasks: Cancer development leads to major changes in the genome as well as in cellular organization and alterations of gene regulatory programs. Such alterations now become visible in unprecedented detail with single cell technologies.

To strengthen our diverse team, we are looking for a postdoctoral fellow (m/f/x) to study tumor heterogeneity, resistance and evolution with single cell multi-omics as part of a collaborative project on sarcomas in childhood and adolescence (HEROES-AYA). We will investigate single-cell behaviors and genetic changes during sarcoma evolution. Using data on somatic genetic evolution and simultaneous single cell RNA- and ATAC-seq, we will study the contribution of genetic and non-genetic driving forces for the cells’ evolution and glioma development. Using multi-omics data integration and machine learning, we will investigate cellular behaviors and gene-regulatory network changes. The project is part of the HEROES-AYA consortium of the German Decade against Cancer, a collaboration between multiple sites in Germany, and the Computational Biology lab of Anna Poetsch on "Biomedical Genomics" at the Biotechnology Center of the TUD, where this position will be based.

The successful candidate will have the opportunity to receive training in cutting-edge methods in multi-omics data integration and the project will provide opportunities to learn, develop, and apply machine learning and deep learning methods on genomics data.

Requirements:

• excellent university and PhD degree with experience in molecular biology, computational biology, genetics, genomics, or equivalent scientific background with an excellent understanding of genome biology
• comprehensive programming experience in python and/or R
• demonstrable experience in multi-omics and/or single cell omics data analysis
• knowledge of machine learning principles and applications
• very good interpersonal and communication skills; in particular, the ability to effectively work in a diverse, collaborative and interdisciplinary research environment
• fluency in English - written and oral. (German is not required)

The BIOTEC/CMCB is a renowned interdisciplinary and international research institute of the TUD that boasts a collaborative spirit and cutting-edge technology platforms, including one of the national genome centres and cutting-edge High Performance Computing resources. The city of Dresden provides numerous chances for scientific exchange and collaboration.

TUD strives to employ more women in academia and research. We therefore expressly encourage women to apply. The University is a certified family-friendly university. We welcome applications from candidates with disabilities. If multiple candidates prove to be equally qualified, those with disabilities or with equivalent status pursuant to the German Social Code IX (SGB IX) will receive priority for employment.

Please submit your detailed application stating the reference number w25-099 with the usual documents, including a letter of motivation, your CV including a list of publications, transcripts of records, and contact details for 2-3 academic references, by July 24, 2025 (stamped arrival date of the university central mail service or the time stamp on the email server of TUD applies), preferably via the TUD SecureMail Portal by sending it as a single pdf file to [email protected] or to: TU Dresden, BIOTEC, Research Group Biomedical Genomics, Dr. Anna Poetsch, Helmholtzstr. 10, 01069 Dresden, Germany . Please submit copies only, as your application will not be returned to you. Expenses incurred in attending interviews cannot be reimbursed.

Reference to data protection: Your data protection rights, the purpose for which your data will be processed, as well as further information about data protection is available to you on the website: .

Company

TU Dresden

Excellence – A matter close to our hearts

Excellence? Elitism? Opportunity or risk? The Excellence Programme, initially launched in 2005 by the German government has aroused passionate debate right from the start and still has the potential to polarise opinion.

TU Dresden (TUD) looks at it this way: excellence is all about performance and having the right attitude. For everyone here at TU Dresden – one of eleven Universities of Excellence in Germany since 2012 – it is also a matter very close to our hearts. Firstly because of the extra motivation and impetus generated, and secondly, because of the way we handle this role.

Our vision for the future can be summed up as follows: “Let us become one of the leading centres for research and teaching, with our own individual character and a special talent for networking, able to attract the best minds in Germany and from further afield.” After all, it is a well-known fact that excellence in research and teaching presupposes excellent conditions. Or, to put it figuratively, for excellent crop yields, you need the right soil and weather.

TU Dresden is a comprehensive university with 18 faculties and works in close collaboration with its top performers: three Clusters of Excellence, including the “Centre for Tactile Internet” (CeTI) , the Cluster “Complexity and Topology in Quantum Matter” (ct.qmat) and the Cluster “Physics of Life” (PoL) . The guiding principle here is that strong individual elements become even stronger when they work together.

The vision for the future takes this principle beyond the confines of the university: with the research network DRESDEN-concept ( D resden R esearch and E ducation S ynergies for the D evelopment of E xcellence and N ovelty), TU Dresden has been creating an alliance of research and cultural facilities in the city, an “excellent playground for excellent people”. This bond is unique in Germany and has evolved over many years. It is not necessary to create anything new here, as it is simply a matter of building further storeys on top of an already solid structure. The measures envisaged as part of the DRESDEN-concept contribute to the overall development of TU Dresden and form an integral part of the university strategy.

Excellence is understood and practised in Dresden as an opportunity for the entire university, and in this spirit, TU Dresden takes those measures that lead to excellence – by the university, for the university – in cooperation with colleagues here and all over the world. But at the same time neither elitist nor exclusive. TUD’s excellence comes from the heart – from and for our about 32,400 students, 600 professors and about 8,400 members of staff. In this way, excellence becomes the basis, the objective, the approach and the driving force. And that’s why being a top performer can also be so rewarding and enjoyable.

Campus Image © Nils Eisfeld

Company info

Location

Dresden
01069 Dresden
DE